Mesotherapy is a treatment that stimulates the mesoderm, the middle layer of the skin, which will, in turn relieve a wide variety of symptoms and ailments. The technique involves the injection of substances to stimulate the mesoderm for various biological purposes. The mesotherapy injections involve extremely small needles that penetrate the interdermal layer of the skin only a very small depth, which is typically four to six millimeters.The number of treatments needed depends on many variables including the condition, the abnormal physiology causing the condition, as well as the chronicity of the problem. A minimum of one to two sessions of mesotherapy are performed to assess the horse’s response. Mesotherapy is effective for a multitude of conditions because it helps reverse the physiology of that condition, and stop the pain spasm cycle.